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许斌

姓名：许斌

职务/职称：教授（正高三级，博士生导师）

邮箱：xubin@t.shu.edu.cn

电话：021-66135607

研究领域：

1. 惰性化学键可控转化

2. 新型药物分子设计及合成

教育经历：

1997.8 - 2000.7 理学博士，中国科学院上海有机化学研究所，金属有机化学，导师：麻生明院士

1994.8 - 1997.6 理学硕士，中国科学院上海有机化学研究所，元素有机化学，导师：朱士正研究员

1988.9 - 1992.7 上海科技大学化学系

工作经历：

2022.2 -至今教授、博士生导师、社区学院副院长

2005.9 -2022.1 教授、博士生导师、永利化学系

2002.9 - 2005.8 Staff Scientist, 美国纽约 VivoQuest, Inc. 药物公司

2000.9 - 2002.8 博士后 (VFA), 美国国立卫生研究院（National Institutes of Health, NIH）,

美国国立糖尿病、消化道及肾脏疾病研究所 (NIDDK)，生物有机化学及药物化学，导师：Kenneth A. Jacobson

代表性科研项目：

1. 异腈参与的惰性化学键可控转化，国家自然科学基金委员会（2022.01－60 2025.12）

2. 基于廉价硝酸铜的可控化学转化与含氮杂环构建，国家自然科学基金 (No. 21871174) (2019.1－2022.12)

3. 基于廉价铜盐阴离子的精准合成及其在心肌纤维化防治中的应用，上海市教育委员会科研创新计划“非共识”项目 (2019-01-07-00-09-E00008) (2019.1－2023.12)

4. 异腈参与的惰性键活化与含氮杂环构建，国家自然科学基金 (No. 21672136) (2017.1－2020.12)

5. 基于氧化胺化反应的含氮杂环合成，国家自然科学基金 (No. 21272149) (2013.1－2016.12)

6. 基于惰性化学键活化的含氮杂环合成，上海市教委科研创新重点项目 (No.14ZZ094) (2014.01－2016.12)

7. 金属催化的1,1-二溴-1-烯烃的多中心反应研究，国家自然科学基金 (No. 20972093) (2010.1－2012.12)

8. 含氮杂环中的多碳-氮键形成反应研究，国家自然科学基金 (No. 20672071) (2007.1－2009.12)

9. 抗丙肝病毒含氮分子库的定向多样性合成及活性研究，上海市浦江人才计划 (No. 07pj14043) (2007.10－2009.9)

代表性学术论文：

68. Cun Yang, Zhi-Xiong Yang, Chang-Hua Ding,* Bin Xu, and Xue-Long Hou*, Development of Dipolarophiles for Catalytic Asymmetric Cycloadditions through Pd-π-allyl zwitterions，Chem. Rec. 2021, ASAP.

67. Weixiang Wang, Tianqi Liu, Chang-Hua Ding,* and Bin Xu*, C(sp3)–H Functionalization with Isocyanides, Org. Chem. Front., 2021, ASAP.

66. Jimin Guo, Jianjian Zha, Tao Zhang, Chang-Hua Ding, Qitao Tan,* Bin Xu*, PdCl2/DMSO-Catalyzed Thiol–Disulfide Exchange: Synthesis of Unsymmetrical Disulfide, Org. Lett, 2021, 23, 3167–3172.

65.Guigang Deng, Tianqi Liu, Yuqin Wang, Bingxin Liu, Qitao Tan,* Bin Xu,*, α-Iminonitriles: Composite Functional Groups for Functionalization of Pyrene, Asian J. Org. Chem. 2021, 10, 262-272.

64. Tianyin Huang, Yang Yu, Hui Wang, Yifan Lin, Yurui Ma, Haoyu Wang, Chang-Hua Ding,* Junjie Xiao,* Bin Xu*, Silver-Promoted Regioselective Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids, Synthesis 2020, 52, 239–245.

63. Juan Du, Yuan-Da Hua, Yang-Jie Jiang, Shuai Huang, Di Chen, Chang-Hua Ding,* Xue-Long Hou*,

Palladium-Catalyzed Asymmetric Decarboxylative [4+2] Dipolar Cycloaddition of 4 Vinyl-1,3-dioxan-2-ones with α,β-Disubstituted Nitroalkenes Enabled by a Benzylic Substituted P,N-Ligand, Org. Lett. 2020, 22, 5375−5379.

62. Leiyang Zhao, Bingxin Liu, Qitao Tan, Chang-Hua Ding*, Bin Xu*, "Silver-Assisted Oxidative Isocyanide Insertion of Ethers: A Direct Approach to β-Carbonyl α-Iminonitriles", Org. Lett. 2019, 21, 9223-9227.

61. Huiwen Chi, Hao Li, Bingxin Liu, Rongxuan Ye, Haoyang Wang, Yin-Long Guo, Qitao Tan* and Bin Xu*, “From Isocyanides to Iminonitriles via Silver-Catalyzed Sequential Insertion of C(sp3)–H Bond”, iScience, 2019, 21, 650-663.

60. Tianyi Huang, Yang Yu, Hui Wang, Yifan Lin, Yurui Ma, Haoyu Wang, Chang-Hua Ding,* Junjie Xiao,* Bin Xu,*, “Silver-Promoted Oxidative Decarboxylative C–H Alkylation of Phenanthridines with Carboxylic Acids”, Synthesis 2019, 51, DOI: 10.1055/s-0039-1690220.

59. Mengjing Jiang, Jimin Guo, Bingxin Liu, Qitao Tan,* and Bin Xu*, “Synthesis of Tellurium-Containing π-Extended Aromatics with Room-Temperature Phosphorescence”, Org. Lett. 2019, 21, 8328-8333.

58. Mingchun Gao, Yuansheng Gan, and Bin Xu*, "From Alkenes to Isoxazolines via Copper-Mediated Alkene Cleavage and Dipolar Cycloaddition", Org. Lett., 2019, 21, 7435-7439.

57. Haoyu Wang, Yurui Ma, Yifan Lin, Jiajie Liu, Rui Chen, Bin Xu,* Yajun Liang*, "An Isoxazole Derivative SHU00238 Suppresses Colorectal Cancer Growth through miRNAs Regulation", Molecules 2019, 24, 2335. (Special Issue Anti-Cancer Drug: Discovery, Development and Combination)

56. Ze-Zhen Jiang, Yang-Jie Jiang, Juan Du, Di Chen, Chang-Hua Ding*, Bin Xu*, Xue-Long Hou*, "Palladium-Catalyzed Asymmetric Heck-Matsuda Reaction of 1,4-Dihydroquinolines with Aryldiazonium Salts", Synthesis 2019, 51, 3269-3276.

55. Yifan Lin, Ke Zhang, Mingchun Gao, Zheyi Jiang, Jiajie Liu, Yurui Ma, Haoyu Wang, Qitao Tan*, Junjie Xiao* and Bin Xu*, "Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones", Org. Biomol. Chem., 2019, 17, 5509–5513.

54. Mingchun Gao, Kaijing Zhou, and Bin Xu, "Copper Nitrate-Mediated Selective Difunctionalization of Alkenes: A Rapid Access to β-Bromonitrates", Adv. Synth. Catal. 2019, 361, 2031-2036.

53. Mingchun Gao, Minfen Zou, Jue Wang, Qitao Tan, Bingxin Liu, and Bin Xu*, "Palladium-Catalyzed Multicomponent Reaction of Alkynes, Carboxylic Acids, and Isocyanides: A Direct Approach to Captodative Olefins", O rg. Lett., 2019, 21, 1596-1597.

52. Tao Zhang, Guigang Deng, Hanjie Li, Bingxin Liu, Qitao Tan,* and Bin Xu,*, "Cyclization of 2-biphenylthiols to dibenzothiophenes under PdCl2/DMSO catalysis", Org. Lett., 2018, 20, 5439-5443.

51. Jian-Guo Liu, Wen-Wen Chen,* Chang-Xue Gu, Bin Xu,* Ming-Hua Xu*, "Access to Spiroindolines and Spirodihydrobenzofurans via Pd-Catalyzed Domino Heck Spiroyclization through C-H Activation and Carbene Insertion", Org. Lett., 2018, 20, 2728-2732.

50. Zhuang Tian, Jiaojiao Xu, Bingxin Liu, Qitao Tan,* Bin Xu*, "Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides", Org. Lett., 2018, 20, 2603-2606.

49. Mingchun Gao, Rongxuan Ye, Weijia Shen and Bin Xu*, "Copper nitrate: a privileged reagent for organic synthesis", Org. Biomol. Chem., 2018, 16, 2602-2618. (Invited Review)

48. Chunling Lan, Zhuang Tian, Xuchun Liang, Mingchun Gao, Wenting Liu, Yu An, Wencheng Fu, Guanming Jiao, Junjie Xiao, and Bin Xu*, "Copper-Catalyzed Aerobic Annulation of Hydrazones: Direct Access to Cinnolines", Adv. Synth. Catal., 2017, 359, 3735-3740.

47. Ze-Zhen Jiang, Ang Gao, Hao Li, Di Chen, Chang-Hua Ding*, Bin Xu*, Xue-Long Hou*, "Enantioselective Synthesis of Chromenes via a Palladium-Catalyzed Asymmetric Redox-Relay Heck Reaction", Chem. Asian J., 2017, 12, 3119-3122.

46. Tengda Si, Bowen Li, Wenrui Xiong, Bin Xu,* and Wenjun Tang*, "Efficient cross-coupling of aryl/alkenyl triflates with acyclic secondary alkylboronic acids", Org. Biomol. Chem., 2017, 15, 9903-9909.

45. Qitao Tan*, Dandan Zhou, Tao Zhang, Bingxin Liu, Bin Xu* "Iodine-doped Sumanene and Its Application for the Synthesis of Chalcogenasumanenes and Silasumanenes", Chem Commun. 2017, 53, 10279-10282.

44. Dandan Zhou, Ya Gao, Bingxin Liu, Qitao Tan*, Bin Xu* "Synthesis of Silicon and Germanium-Containing Heterosumanenes via Rhodium-Catalyzed Cyclodehydrogenation of Silicon/Germanium–Hydrogen and Carbon–Hydrogen Bonds", Org. Lett. 2017, 19, 4628-4631.

43. Zong-Feng Zhang, Dong-Xing Zhu, Wen-Wen Chen, Bin Xu*, Ming-Hua Xu*, "Enantioselective Synthesis of gem-Diaryl Benzofuran-3(2H)-ones via One-Pot Asymmetric Rhodium/Palladium Relay Catalysis", Org. Lett. 2017, 19, 2726-2729.

42. Xiaohu Hong, Qitao Tan, Bingxin Liu, Bin Xu*, "Isocyanide Induced Activation of Copper Sulfate: Direct Access to Functionalized Heteroarene Sulfonic Esters", Angew. Chem., Int. Ed. 2017, 56, 3961-3965.

41. Yingying Li, Mingchun Gao, Bingxin Liu, Bin Xu*, "Copper Nitrate-Mediated Chemo- and Regioselective Annulation from Two Different Alkynes: A Direct Route to Isoxazoles", Org. Chem. Front. 2017, 4, 445-449.

40. Bingrui Song, Bin Xu*, "Metal-catalyzed C–H functionalization involving isocyanides", Chem. Soc. Rev., 2017, 46, 1103-1123. (封面论文）

39. Hao Li, Ang Gao, Xiu-Yan Liu, Chang-Hua Ding*, Bin Xu*, Xue-Long Hou*, "Kinetic Resolution of 5-Substituted-Cyclohexenols by Pd-Catalyzed Asymmetric Redox-Relay Heck Reaction", Synthesis 2017, 49, 159-166.

38. Mingchun Gao, Bin Xu*, "Copper Nitrate-Mediated Regio- and Stereoselective Difunctionalization of Alkynes: A Direct Approach to a-Chloro-β-nitroolefins", Org. Lett. 2016, 18, 4746-4749.

37. Xu Zhang, Bin Xu* and Ming-Hua Xu*, "Rhodium-catalyzed asymmetric arylation of N- and O-containing cyclic aldimines: facile and efficient access to highly optically active 3,4-dihydrobenzo[1,4]oxazin-2-ones and dihydroquinoxalinones", Org. Chem. Front., 2016, 3, 944-948.

36. Qitao Tan and Bin Xu,* "C−H Bond Activation as a Powerful Tool in the Construction of Biologically Active Nitrogen Containing Heterocycles", Studies in Natural Products Chemistry, 2016, 50, 299-340. (Invited book chapter).

35. Mingchun Gao and Bin Xu,* "Transition Metal-Participated Synthesis and Utilization of N-containing Heterocycles: Exploring for Nitrogen Sources", Chem. Rec. 2016, 16, 1701-1714. (个人研究综述）

34. Hong Mao, Mingchun Gao, Bingxin Liu and Bin Xu,* "Manganese(II)-catalyzed modular synthesis of isoquinolines from vinyl isocyanides and hydrazines", Org. Chem. Front. 2016, 3, 516-521.

33. Qitao Tan,* Huanhuan Chen, Huaida Xia, Bingxin Liu and Bin Xu,* "Parent and Trisubstituted Triazacoronenes: Synthesis, Crystal Structure and Physicochemical Properties", Chem. Commun. 2016, 52, 537-540. (国内外媒体亮点推介：Synfacts；X-Mol.)

32. Hao Li, Shi-Li Wan, Changhua Ding,* Bin Xu* and Xue-Long Hou, "Kinetic Resolution of 2-Substituted-2,3-dihydrofurans by Palladium-Catalyzed Asymmetric Heck ", RSC Advances 2015, 5, 75411-75414.

31. Mingchun Gao, Yingying Li, Yuansheng Gan and Bin Xu*, "Copper Nitrate-Mediated Regioselective [2+2+1] Cyclization of Alkynes with Alkenes: A Cascade Approach to Δ2-Isoxazolines", Angew. Chem., Int. Ed.，2015, 54, 8795-8799. （封面论文）(国内外媒体亮点推介：Synfacts；中国科学报；教育部科技发展中心；科学网；X-Mol)

30. Zhengwei Ding, Qitao Tan*, Bingxin Liu, Ke Zhang, Bin Xu*, "Copper-Promoted Oxidative C−H Bond Amination of Hydrazones: Synthesis of 1H-Indazoles and 1H-Pyrazoles", Acta Chimica Sinica, 2015, 73, 1302-1306. (主编邀请稿, Special topic: C-H activation)

29. Diao Chen, Xu Zhang, Wei-Yi Qi, Bin Xu and Ming-Hua Xu*, "Rhodium(I)-Catalyzed Asymmetric Carbene Insertion into B−H Bonds: Highly Enantioselective Access to Functionalized Organoboranes", J. Am. Chem. Soc., 2015, 137, 5268–5271. （封面论文）

28. Zhengwei Ding, Qitao Tan, Mingchun Gao and Bin Xu*, "Copper-catalyzed Aerobic Cascade Cycloamination and Acyloxylation: a Direct Approach to 4-Acyloxy-1H-pyrazoles", Org. Biomol. Chem. 2015, 13, 4642-4646.

27. Hao Wang and Bin Xu*, "Recent Advances in Inert Bonds Activation with Isocyanides", Chin. J. Org. Chem. 2015, 35, 588-602. (主编邀请综述)

26. Hao Li, Changhua Ding*, Bin Xu*, Xuelong Hou*, "Recent Developments in Palladium-Catalyzed Asymmetric Intermolecular Heck Reaction", Acta Chimica Sinica, 2014, 72, 765-770. (Review)

25. Guangyin Qian, Xiaohu Hong, Bingxin Liu, Hong Mao and Bin Xu*, "Rhodium-catalyzed Regioselective C–H Chlorination of 7-Azaindoles Using 1,2-Dichloroethane", Org. Lett. 2014, 16, 5294-5297.

24. Xiaohu Hong, Hao Wang, Bingxin Liu and Bin Xu*, "Ruthenium-Catalyzed Double-Fold C-H Tertiary Alkoxycarbonylaton Arenes Using Di-tert-butyl Dicarbonate", Chem Commun. 2014, 50, 14129-14132.

23. Hao Wang, Yang Yu, Xiaohu Hong and Bin Xu*, "Mn(II)/O2-Promoted Oxidative Annulation of Vinyl Isocyanides with Boronic Acids: Synthesis of Multi-substituted Isoquinolines", Chem Commun. 2014, 50, 13485-13488.

22. Guangyin Qian, Bingxin Liu, Qitao Tan, Siwen Zhang, and Bin Xu*, "Hypervalent Iodine(III)-Promoted Direct Synthesis of Imidazo[1,2-a]pyrimidines", Eur. J. Org. Chem. 2014, 2014, 4837-4843.

21. Tao Fang, Qitao Tan, Zhengwei Ding, Bingxin Liu and Bin Xu*, " Pd-Catalyzed Oxidative Annulation of Hydrazides with Isocyanides: Synthesis of 2-Amino-1,3,4-oxadiazoles", Org. Lett. 2014, 16, 2342-2345. (Highlighted by Org. Chem. Portal 网站)

20. Hao Wang, Yang Yu, Xiaohu Hong, Qitao Tan and Bin Xu*, " Rhodium-Catalyzed Direct ortho C–N Bond Formation of Aromatic Azo Compounds with Azides", J. Org. Chem. 2014, 79, 3279-3288.

19. Xiaohu Hong, Hao Wang, Guangyin Qian, Qitao Tan and Bin Xu*, " Rhodium-Catalyzed Direct C–H Bond Cyanation of Arenes with Isocyanide", J. Org. Chem. 2014, 79, 3228-3237.

18. Xiaomei Huang, Shuguang Xu, Qitao Tan, Mingchun Gao, Minjie Li and Bin Xu*, "Copper-mediated Tandem Reaction through Isocyanides N–H Bond Insertion: Efficient Access to Unsymmetrical Tetrasubstituted Ureas", Chem Commun. 2014, 50, 1465-1468.

17. Jie Sun, Qitao Tan, Wusong Yang, Bingxin Liu and Bin Xu*, “Copper-Catalyzed Aerobic Oxidative Annulation and Carbon-Carbon Bond Cleavage of Arylacetamides: Domino Synthesis of Fused Quinazolinones”, Adv. Synth. Catal. 2014, 356, 388-394.

16. Wenting Liu, Xiaohu Hong, Bin Xu*, "Rhodium-Catalyzed Oxidative Coupling of Aryl Hydrazones with Internal Alkynes: Efficient Synthesis of Multisubstituted Isoquinolines" (主编邀请稿, Special topic: Rhodium catalysis), Synthesis 2013, 45, 2137-2149.

15. Jie Sun, Bingxin Liu, and Bin Xu*, "Copper-Catalyzed Tandem Oxidative Cyclization of Arylacetamides: Efficient Access to N-Functionalized Isatins", RSC Advances 2013, 3, 5824-5827.

14. Guifei Li, Zhengwei Ding, and Bin Xu*, "Rhodium-Catalyzed Oxidative Annulation of Sulfonylhydrazones with Alkenes", Org. Lett. 2012, 14, 5338-5341.

13. Shuguang Xu, Xiaomei Huang, Xiaohu Hong, and Bin Xu*, "Palladium-Assisted Regioselective C–H Cyanation of Heteroarenes Using Isonitrile as Cyanide Source", Org. Lett. 2012, 14, 4614-4617.

12. Bingxin Liu, Xiaohu Hong, Dong Yan, Shuguang Xu, Xiaomei Huang, and Bin Xu*, "Palladium-Catalyzed Tandem Allenyl and Aryl C–N Bond Formation: Efficient Access to N-Functionalized Multi-substituted Indoles", Org. Lett. 2012, 14, 4398-4401.

11. Jun Shao, Xiaomei Huang, Xiaohu Hong, Bingxin Liu and Bin Xu*, "Synthesis of N–Alkyl Substituted 4-Quinolones via Tandem Alkenyl and Aryl C–N Bond Formation" (主编邀请稿, Special topic: Tandem reaction), Synthesis 2012, 44, 1798-1808. Highlighted by Org. Chem. Portal 网站

10. Jun Shao, Xiaomei Huang, Siyuan Wang, Bingxin Liu, Bin Xu*, "A straightforward synthesis of N-monosubstituted a-keto amides via aerobic benzylic oxidation of amides", Tetrahedron 2012, 68, 573-579.

9. Chengming Wang, Caiyun Sun, Fei Weng, Mingchun Gao, Bingxin Liu and Bin Xu*, "Unexpected formation of (Z)-3-(halomethylene) isoindolinones from gem-dihalovinylbenzonitriles: Efficient synthesis of enyne-containing isoindolinones", Tetrahedron Lett. 2011, 52, 2984-2989.

8. Xiaojian Zheng, Bingrui Song, Guifei Li, Bingxin Liu, Hongmei Deng and Bin Xu*, "Direct synthesis of ortho-dihalogenated arylpyrimidines using calcium halides as halogen sources", Tetrahedron Lett. 2010, 51, 6641-6645.

7. Xiaojian Zheng, Bingrui Song and Bin Xu*, "Palladium-Catalyzed Regioselective C-H Bond ortho-Acetoxylation of Arylpyrimidines", Eur. J. Org. Chem. 2010, 4376-4380.

6. Fei Weng, Chengming Wang and Bin Xu*, "Direct C-H bond arylation of 2-hydroxybenzaldehydes with arylboronic acids via ligand-free palladium catalysis", Tetrahedron Lett. 2010, 51, 2593-2596.

5. Bingrui Song, Xiaojian Zheng, Jun Mo and Bin Xu*, "Palladium-Catalyzed Monoselective Halogenation of C-H Bonds: Efficient Access to halogenated Arylpyrimidines using Calcium Halides", Adv. Synth. Catal. 2010，352，329-335.

4. Tiankun Zhao and Bin Xu*, "Palladium-Catalyzed Tandem Amination Reaction for the Synthesis of 4-Quinolones", Org. Lett. 2010, 12, 212-215. (Highlighted by Synfacts 2010, 4, 0408.) (Highlighted by Org. Chem. Portal 网站)

3. Wenchao Ye, Jun Mo, Tiankun Zhao and Bin Xu*, "Palladium-Catalyzed Amidation-Hydrolysis Reaction of gem-Dihaloolefins: Efficient Synthesis of Homologated Carboxamides from Ketones", Chem Commun. 2009, 3246-3248. (Highlighted by Org. Chem. Portal 网站; see, D. F. Taber, Org. Chem. Highlights 2010, March 22.)

2. Caiyun Sun and Bin Xu*, "A Tandem Elimination-Cyclization-Suzuki Approach: Efficient One-pot Synthesis of Functionalized (Z)-3-(Arylmethylene)isoindolin-1-ones", J. Org. Chem. 2008, 73, 7361-7364.

1. Bingrui Song, Siyuan Wang, Caiyun Sun, Hongmei Deng and Bin Xu*, "Cesium Carbonate Promoted Aerobic Oxidation of Arylacetamides: An Efficient Access to N-Substituted a-keto amides", Tetrahedron Lett. 2007, 48, 8982-8986.

（最后更新日期：2022.3.23）